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Potassium Channel Subfamily A Member 1 (Kv1.1)
- Target
- Kv1.1
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel, Shaker family channel, Delayed rectifier K+ channel
01
Overview
Kv1.1 is a voltage-gated potassium channel that plays a critical role in regulating neuronal excitability and action potential repolarization. It is predominantly expressed in the brain and central nervous system, but also found in peripheral nerves and heart tissue. Mutations in the KCNA1 gene, which encodes Kv1.1, can lead to neurological disorders such as episodic ataxia type I and epilepsy. Autoimmune reactions against Kv1.1 can cause Isaacs syndrome. Kv1.1 forms tetrameric channels and its function is influenced by interactions with auxiliary subunits.
- Other names
- HuK1RBK1MBKHBK1voltage-gated potassium channel subunit Kv1.1voltage-gated K+ channel HuKIAEMK
02
Mechanism of action
Modulation of neuronal excitability through voltage-dependent potassium conductance
03
Biological functions
Regulation of neuronal excitabilityRepolarization phase of action potentialsModulation of neurotransmitter releaseSelective transmembrane transport of potassium ions
04
Disease associations
Episodic ataxia type IEpilepsyIsaacs syndromeNeurological disordersNeuromuscular disorders
05
Safety considerations
Altered neuronal excitabilityPotential for seizuresCardiac effects due to expression in heart tissue
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