Potassium Channel Subfamily K Member (KCNK)

Potassium channel subfamily K members (KCNK), also known as two-pore-domain potassium channels (K2P), are a family of potassium ion channels that play a crucial role in setting and stabilizing the resting membrane potential in various cell types. These channels are characterized by their unique structure, comprising four transmembrane domains and two pore-forming loops per subunit, and their ability to allow passive movement of potassium ions across the cell membrane. They are widely expressed throughout multiple organ systems, including the central nervous system, cardiovascular system, gastrointestinal tract, and genitourinary system. Their activity is regulated by diverse factors such as oxygen tension, pH changes, mechanical stretch, temperature shifts, and G-protein-coupled receptor signaling pathways. Dysregulation or mutation of certain family members has been implicated in neurological disorders, cardiac arrhythmias, and hypertension.

Other names

Two-Pore-Domain Potassium ChannelK2P channel

Modulation of potassium ion flow across cell membranes, affecting membrane potential and cellular excitability.