Potassium channel subfamily K member 17 (KCNK17)

Potassium channel subfamily K member 17 (KCNK17) encodes a two-pore domain potassium (K2P) channel, also known as TASK-4 or TALK-2, that conducts outward rectifying potassium currents and helps establish the resting membrane potential in excitable cells. It is activated at alkaline pH values, displaying a sensitivity unique among K2P channels. KCNK17 is highly expressed in tissues such as the heart, pancreas, liver, and brain, where it regulates electrical excitability. Gain-of-function mutations are implicated in cardiac conduction disorders and idiopathic ventricular fibrillation, while genetic variants have been associated with increased risk of ischemic stroke and cerebral hemorrhage. It is considered a potential therapeutic target for arrhythmias and stroke due to its critical role in cardiac and cerebrovascular excitability.

Other names

K2P17.1TALK-2TALK2TASK-4TASK42P domain potassium channel Talk-2Acid-sensitive potassium channel protein TASK-4TWIK-related acid-sensitive K(+) channel 4TWIK-related alkaline pH-activated K(+) channel 2TWIK-related acid-sensitive K+ 4potassium channel, two pore domain subfamily K, member 17

Modulation (typically inhibition or potentiation) of channel activity affects membrane potential and excitability of cells, particularly in cardiac and neural tissues. Alkaline pH activation is unique among K2P channels.