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Potassium channel subfamily K member 2 (KCNK2)
- Target
- KCNK2
- Molecular classification
- Ion channel, Potassium channel, Two-pore-domain background potassium channel, K2P channel
01
Overview
Potassium channel subfamily K member 2 (KCNK2), also known as TREK-1, is a two-pore-domain background potassium channel that helps maintain the resting membrane potential. It is involved in neuroprotection, modulation of anesthesia response, ischemia tolerance, pain perception modulation, and depression resistance mechanisms. The channel is activated by anionic lipids, certain anesthetics, membrane stretching, intracellular acidosis, and heat. Dysregulation has been associated with neurological disorders such as epilepsy.
- Other names
- TREK-1TREK1K2P2.1TREKTwo-pore domain background potassium channel
02
Mechanism of action
Channel opening via anionic lipids, anesthetics, membrane stretching, intracellular acidosis, or heat; indirect activation via phospholipase D2 (PLD2)
03
Biological functions
ElectrogenesisRegulation of resting membrane potentialNeuroprotectionModulation of anesthesia responseRegulation of neuronal excitability
04
Disease associations
Neurological disordersEpilepsyIschemiaPain perceptionDepressionTumors (in animal models)
05
Safety considerations
Potential for off-target effects due to widespread expressionDysregulation leading to neurological disorders
06
Interacting drugs
Anesthetics (e.g., propofol)
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