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Potassium channel subfamily K member 3 (KCNK3)
- Target
- KCNK3
- Molecular classification
- Ion channel, Potassium channel, Two-pore domain potassium channels (K2P)
01
Overview
Potassium channel subfamily K member 3 (KCNK3) is a pH-dependent, voltage-insensitive background potassium channel that regulates resting membrane potential in various cell types. It is highly expressed in the central nervous system and peripheral tissues such as heart, adrenal gland, pulmonary arterial smooth muscle cells (PASMCs), and kidney. Mutations or loss-of-function variants are linked to heritable forms of pulmonary arterial hypertension (PAH).
- Other names
- TASKTASK1TBAK1OAT1PPH4K2P3.1
02
Mechanism of action
Pharmacological activation can reverse experimental PH models; current research is focused on identifying KCNK3 activators.
03
Biological functions
Background/leak potassium conductanceRegulates resting membrane potentialNeuronal excitability modulationChemoreception for O₂/CO₂ sensingAdrenal gland developmentAldosterone secretionProtection against brain ischemiaRegulation of thermogenesiscAMP-PKA signaling
04
Disease associations
Pulmonary arterial hypertension
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