Potassium channel subfamily K member 4 (KCNK4)

Potassium channel subfamily K member 4 (KCNK4), also known as TRAAK or K2P4.1, is a two-pore domain potassium ion channel predominantly expressed in neural tissues, especially in the cerebral cortex and hippocampus. It functions as a mechanosensitive and lipid-sensitive channel essential for maintaining the resting membrane potential and regulating neuronal excitability. KCNK4 is activated by mechanical stretch, polyunsaturated fatty acids, temperature, phosphorylation, and pH. Dysfunction or mutations in KCNK4 have been linked to neurodevelopmental diseases such as FHEIG syndrome and epilepsy, with emerging evidence implicating it in broader neurological and potentially cardiovascular conditions. KCNK4 is also targeted by several drug classes, including antiepileptics and volatile anesthetics, making it a clinically relevant ion channel in neuroprotection, neuromodulation, and potential therapeutic intervention.

Other names

TRAAKK2P4.1TWIK-related arachidonic acid-stimulated potassium channel proteinTwo-pore potassium channel KT4.1Two pore K(+) channel KT4.1TRAAK1FHEIG-associated potassium channelPotassium two pore domain channel subfamily K member 4

Antiepileptic drugs: Stabilization of neuronal membrane potential via channel modulation Neuroprotective action: Opening channels reduces neuronal excitability during ischemic/hypoxic stress Anesthetics/antidepressants: Modulation of channel activity to reduce neural firing or alter mood state