Target intelligence / Profile preview

Potassium channel subfamily K member 5 (TASK-2) (TASK-2)

Target: TASK-2
Molecular classification: Ion channel, Two-pore domain potassium channel

Overview

Other names: KCNK5K2P5.1TWIK-related acid-sensitive K+ channel 2

Biological functions

Maintenance of resting membrane potential (UniProt O95279)pH sensing (PubMed: 11031251)Cell volume regulation (PubMed: 15123805)Bicarbonate reabsorption (PubMed: 15123805)Respiratory chemoreception (PubMed: 20679138)

Disease associations

Metabolic acidosis (PubMed: 15123805)Balkan endemic nephropathy (PubMed: 24615991)Respiratory disorders (PubMed: 20679138)Cancer (PubMed: 12620410)

Interacting drugs

Clofilium (UniProt O95279)

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