Potassium Channel Subfamily K Member 9 (KCNK9)

Potassium channel subfamily K member 9 (KCNK9), also known as TASK-3, is a two-pore domain potassium channel (K2P) that contributes to background or "leak" potassium currents. It stabilizes resting membrane potential and regulates cellular excitability, particularly in neurons. KCNK9 is widely expressed, especially in the brain (cerebellum), pancreas, and placenta. Mutations in KCNK9, particularly when maternally inherited due to genomic imprinting, cause KCNK9 imprinting syndrome, characterized by congenital hypotonia, feeding difficulties, intellectual disability, and delayed development. Its activity is modulated by extracellular pH, arachidonic acid, and phorbol esters.

Other names

TASK-3TASK3TWIK-related acid-sensitive K(+) channel 3Two pore potassium channel KT3.2Acid-sensitive potassium channel protein TASK‑3TASK‑3/TASK‑3TWIK-related acid-sensitive (K+) channel 3Two pore (K+) channel KT3.2

Not applicable; the description provided does not include any drugs that target this molecule. However, it does mention inhibition by arachidonic acid and phorbol esters, which can be explored further.