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Target intelligence / Profile preview
Potassium Channel Subfamily K Member S (IKs)
- Target
- IKs
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
The IKs channel, also known as the slow delayed rectifier potassium current, is a crucial cardiac potassium channel complex primarily formed by the co-assembly of KCNQ1 and KCNE1. This heteromeric complex is essential for proper cardiac repolarization and adaptation to physiological stress. Mutations in either component can cause inherited arrhythmia syndromes like Long QT Syndrome.
- Other names
- Slow delayed rectifier potassium currentKCNQ1/KCNE1 channel
02
Mechanism of action
Modulation of potassium ion flow across cell membranes, affecting cardiac action potential duration and repolarization.
03
Biological functions
Cardiac repolarizationRegulation of cardiomyocyte excitabilityAdaptation to stress (sympathetic stimulation)Regulation of heart rate
04
Disease associations
Long QT SyndromeArrhythmiaJervell-Lange-Nielsen syndrome
05
Safety considerations
QT prolongationTorsades de pointesSudden death
06
Interacting drugs
Antiarrhythmics
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