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Potassium Channel Subfamily KQT Member 4
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
Potassium channel subfamily KQT member 4 (KCNQ4), also known as voltage-gated potassium channel subunit Kv7.4, is a protein that forms part of a family of voltage-gated potassium channels essential for regulating neuronal excitability and maintaining membrane potential. It plays a critical role in regulating membrane potential in excitable cells, especially within sensory cells of the cochlea. Mutations in KCNQ4 cause nonsyndromic sensorineural deafness type 2 (DFNA2).
- Other names
- DFNA2DFNA2AKV7.4Voltage-gated potassium channel subunit Kv7.4
02
Mechanism of action
Retigabine and ML213 activate/open the channel, increasing potassium ion transport. Muscarinic acetylcholine receptor M1 activation inhibits the channel.
03
Biological functions
Regulation of membrane potentialTransmission of nerve impulseSensory perception - hearingPotassium channel activityVoltage-gated ion channel activityIon transport
04
Disease associations
Nonsyndromic sensorineural deafness type 2 (DFNA2)Progressive hearing loss
05
Safety considerations
Retigabine has limited clinical use due to side effects.
06
Interacting drugs
Retigabine
1 more in the full profile.
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