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Target intelligence / Profile preview
Potassium channel subfamily KQT member 5 (Kv7.5)
- Target
- Kv7.5
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
Potassium channel subfamily KQT member 5 (KCNQ5), also known as Kv7.5, is a voltage-gated potassium channel subunit that plays a critical role in regulating neuronal excitability. It contributes to the M-current, a slow-activating/deactivating potassium conductance crucial for setting the threshold for action potential firing. Mutations in KCNQ5 are associated with neurodevelopmental disorders, intellectual disability, and epilepsy, highlighting its importance in neuronal function. Its activity is modulated by various pharmacological agents, including inhibitors and activators, offering potential therapeutic avenues for related disorders.
- Other names
- KCNQ5MRD46Potassium channel subunit alpha KvLQT5Voltage-gated potassium channel subunit Kv7.5
02
Mechanism of action
Modulation of M-type potassium currents, influencing neuronal excitability.
03
Biological functions
Regulation of neuronal excitabilityRegulation of M-currentPotassium ion transmembrane transport
04
Disease associations
Intellectual disability syndromesEpileptic encephalopathyNeurodevelopmental disorders
05
Safety considerations
Potential for altered neuronal excitabilitySide effects related to potassium channel modulation
06
Interacting drugs
Barium
4 more in the full profile.
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