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Potassium Channel Subfamily Q Member 3 (KCNQ3)

Target: KCNQ3
Molecular classification: Voltage-gated potassium channels, Ion channel, Kv family, Subfamily Q

Overview

Potassium channel subfamily Q member 3 (KCNQ3) is a voltage-gated potassium channel subunit that plays a crucial role in regulating neuronal excitability. It forms part of the M-channel, which is responsible for the M-current, a potassium current that helps stabilize the membrane potential and prevent excessive neuronal firing. Mutations in KCNQ3 are associated with benign familial neonatal seizures.

Other names: BFNC2EBN2KV7.3

Mechanism of action

Retigabine activates KCNQ3 channels, increasing potassium ion conductance and hyperpolarizing the cell membrane, thus reducing neuronal excitability.

Biological functions

Regulation of neuronal excitabilityStabilizing membrane potentialControlling neuronal firing rate

Disease associations

Benign familial neonatal seizures (BFNS)Epilepsy

Safety considerations

Excessive activation could lead to neuronal hypoexcitability.

Interacting drugs

Retigabine

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