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Potassium channel TASK-3 (TASK-3)
- Target
- TASK-3
- Molecular classification
- Ion channel, Potassium channel, Two-pore domain (K2P) potassium channels
01
Overview
TASK-3 (KCNK9) is a two-pore domain potassium (K2P) channel that contributes to the resting membrane potential and regulates neuronal excitability. It is highly expressed in the central nervous system and is modulated by extracellular pH and various pharmacological agents. Dysfunction or altered expression of TASK-3 has been implicated in several diseases, including sleep disorders, neurodegenerative diseases, and cancer.
- Other names
- KCNK9K2P9.1TWIK-related acid-sensitive K+ channel 3
02
Mechanism of action
Inhibition of TASK-3 channel activity, leading to altered neuronal excitability and membrane potential.
03
Biological functions
Regulation of resting membrane potentialRegulation of neuronal excitabilityModulation of neurotransmitter release
04
Disease associations
Sleep disordersNeurodegenerative diseasesCognitive impairmentMajor depressive disorderCancer
05
Interacting drugs
Doxapram
3 more in the full profile.
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