Potassium channel tetramerization domain-containing protein 10 (KCTD10)

Potassium channel tetramerization domain-containing protein 10 (KCTD10) is a soluble, *non-channel* BTB/POZ domain-containing adapter protein that functions primarily as a substrate adaptor for Cullin3 (CUL3)-based E3 ubiquitin ligase complexes, mediating targeted protein degradation[1][3][4]. Its N-terminal BTB domain enables oligomerization, protein-protein interactions, and direct binding to CUL3, forming heterodecameric E3 ligase complexes. KCTD10 has diverse roles, including regulation of protein degradation, modulation of cytoskeleton, lipid and cholesterol metabolism, signal transduction, and vascular remodeling. Recent studies indicate critical functions in cardiovascular health, influencing vascular smooth muscle proliferation, endothelial function, and inflammatory response, with a key role in the pathogenesis of atherosclerosis and potential as a therapeutic target for vascular diseases[2]. KCTD10 also interacts with a complex network of miRNAs, lncRNAs, and regulatory proteins that modulate downstream signaling pathways essential for tissue repair, immune function, and cellular homeostasis[2].

Other names

BTB/POZ domain-containing adapter for CUL3-mediated RhoA degradation protein 3KCTD10ULR061MSTP028hBACURD3BTBD28Potassium channel tetramerization domain-containing protein 10potassium channel tetramerisation domain containing 10

Modulation of vascular smooth muscle cell proliferation; Regulation of endothelial barrier function; Control of inflammatory signaling (as KCTD10 modulates inflammatory pathways, particularly those involved in atherosclerosis)