Potassium channel tetramerization domain-containing protein 11 (KCTD11)

Potassium channel tetramerization domain-containing protein 11 (KCTD11) is an adaptor protein characterized by a conserved N-terminal BTB/POZ domain which mediates protein-protein interactions and oligomerization[3][4][7]. It is upregulated by neurogenic signals including retinoic acid, EGF, and NGF and acts as both a marker and regulator of neuronal differentiation[2][4]. KCTD11 is a tumor suppressor involved in inducing apoptosis and growth arrest, notably inhibiting cell growth and tumorigenicity of medulloblastoma[4][7]. It exerts biological activity partly by acting as a substrate adaptor within the BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex, targeting HDAC1 for ubiquitination and degradation which in turn impacts transcription factor GLI1 and the Hedgehog signaling pathway, crucial for neurodevelopment and oncogenic transformation[3][4][7]. Loss or knockdown of KCTD11 impairs neural differentiation antagonism and sustains proliferation, contributing to tumorigenesis, particularly in the cerebellum[4]. No approved drugs are specifically known to target KCTD11, but its molecular function makes it a candidate for research in cancer therapeutics and neurodevelopmental modulation. No direct evidence of currently approved drugs or biomarkers in clinical use; mechanisms and roles are based on experimental and preclinical studies.

Other names

BTB/POZ domain-containing protein KCTD11C17orf36RENKCASH1RING-type E3 ubiquitin transferase subunit KCTD11retinoic acid-EGF-NGF-induced gene proteinpotassium channel tetramerization domain containing 11REN/KCTD11

Substrate-specific adaptor for the BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex targeting HDAC1 for ubiquitination and degradation[3][4][7]; Inhibition of Hedgehog pathway through regulation of GLI1 acetylation and localization[4][7]