Potassium channel tetramerization domain-containing protein 2 (KCTD2)

Potassium channel tetramerization domain-containing protein 2 (KCTD2) is a soluble, non-channel protein that functions primarily as an adaptor for Cullin3-dependent E3 ubiquitin ligase complexes, facilitating the ubiquitination and degradation of specific substrates including the oncogene c-Myc. The protein has a conserved BTB/POZ domain that mediates oligomerization and protein interactions. KCTD2 is implicated in transcriptional repression, cytoskeleton regulation, and modulation of stem cell features in tumors. It is evolutionarily related to the tetramerization domains of voltage-gated potassium channels, despite not forming a channel itself. Its role in the ubiquitination pathway has been highlighted in cancers, especially malignant gliomas, where its loss leads to increased c-Myc levels, promoting tumor growth and stemness[1][2][5].

Other names

BTB/POZ domain-containing protein KCTD2KCTD2KIAA0176Potassium channel tetramerization domain-containing protein 2potassium channel tetramerisation domain containing 2

Adaptor-mediated ubiquitination and degradation of target proteins such as c-Myc (a key stem cell factor and oncogene); Suppression of stem cell-like features and aerobic glycolysis in glioma cells via c-Myc regulation