Potassium channel tetramerization domain-containing protein 6 (KCTD6)

Potassium channel tetramerization domain-containing protein 6 (KCTD6) is a member of the KCTD protein family, named for their N-terminal BTB/POZ domain, which bears sequence similarity to potassium channel tetramerization domains. KCTD6 primarily serves as a substrate-specific adaptor for cullin-3 E3 ubiquitin ligase complexes, mediating the selective ubiquitination and proteasomal degradation of proteins such as muscle ankyrin-1 isoform 5 and HDAC1. This regulation influences processes such as muscle protein turnover and Hedgehog pathway signaling. KCTD6 forms parallel homotetrameric complexes via its BTB/POZ domain and is important for maintenance of muscle structure and potentially other cellular processes. Dysfunction or altered expression of KCTD6 has been linked to muscle disorders and may have relevance in developmental and oncogenic contexts.

Other names

KCTD6BTB/POZ domain-containing protein KCTD6KCASH3MGC27385Potassium channel tetramerization domain-containing protein 6KCASH3 proteinPotassium channel tetramerisation domain containing 6