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Potassium-chloride co-transporter 2 (KCC2)
- Target
- KCC2
- Molecular classification
- Solute Carrier Family 12, Cation-Chloride Cotransporter, Transporter
01
Overview
Potassium-chloride co-transporter 2 (KCC2), encoded by the SLC12A5 gene, is a member of the SLC12 family of cation-chloride cotransporters. It mediates the coupled export of potassium (K⁺) and chloride (Cl⁻) ions across the plasma membrane, maintaining low intracellular chloride concentrations. This is essential for cell volume regulation and inhibitory neurotransmission mediated by GABA and glycine. Dysfunction or downregulation of KCC2 is implicated in neurological disorders like epilepsy and neuropathic pain.
- Other names
- SLC12A5
02
Mechanism of action
Inhibition of KCC2 increases intracellular chloride concentration, reducing the hyperpolarizing effect of GABAergic signaling.
03
Biological functions
Ion transportCell volume regulationGABAergic neurotransmissionInhibitory neurotransmission
04
Disease associations
EpilepsyNeuropathic pain
05
Safety considerations
Pharmacological targeting remains challenging due to limited selectivity of available inhibitors.Dysregulation can lead to neuronal hyperexcitability.
06
Interacting drugs
Bumetanide
1 more in the full profile.
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