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Potassium-chloride transporter member 4 (KCC1)

Target: KCC1
Molecular classification: Transporter, Solute Carrier Family 12

Overview

Potassium-chloride transporter member 4 (KCC1) is a membrane protein that mediates the coupled movement of potassium (K⁺) and chloride (Cl⁻) ions across the plasma membrane. The transport is electroneutral and is typically activated by cell swelling. KCC1 plays a key role in maintaining cell volume homeostasis by facilitating the efflux of K⁺ and Cl⁻ ions when cells are exposed to hypotonic conditions. It may also contribute to other physiological processes such as regulation of intracellular chloride concentration and cellular osmotic balance.

Other names: SLC12A4Chloride potassium symporter 4hKCC1

Biological functions

Ion transportCell volume regulationOsmoregulation

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