Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium-chloride transporter member 5 (KCC2)
- Target
- KCC2
- Molecular classification
- Transporter, Cation-chloride cotransporter family (SLC12)
01
Overview
Potassium-chloride transporter member 5 (KCC2 / SLC12A5) is a neuron-specific chloride-potassium symporter that plays a critical role in establishing and maintaining the chloride ion gradient in neurons by ensuring low intracellular chloride concentrations. This function is essential for synaptic inhibition, neuronal excitability regulation, and neuroprotection against excitotoxicity. Mutations or reduced expression of SLC12A5/KCC2 are associated with neurological disorders such as epilepsy and certain forms of encephalopathy.
- Other names
- SLC12A5Chloride potassium symporter 5EIEE34EIG14hKCC2DEE34
02
Mechanism of action
Electroneutral potassium-chloride cotransport
03
Biological functions
Potassium/chloride exportMaintenance of low intracellular chloride concentrationSynaptic inhibitionNeuroprotectionModulates plasticityNeuronal Cl− homeostasis
04
Disease associations
Epilepsy syndromes (DEE34/EIEE34)Motor/spastic disordersHepatocellular carcinoma
Beyond the preview
Go deeper on Potassium-chloride transporter member 5 (KCC2).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium-chloride transporter member 5 (KCC2).