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Potassium Inwardly Rectifying Channel Subfamily J Member 3 (KCNJ3)
- Target
- KCNJ3
- Molecular classification
- Ion channel, Potassium channel, Inward-rectifier potassium channel, G protein-coupled inwardly rectifying potassium channel (GIRK)
01
Overview
KCNJ3 encodes an integral membrane protein that functions as an inward-rectifier type potassium channel, allowing potassium ions to flow more easily into the cell than out of it. It is a member of the G protein-coupled inwardly rectifying potassium channels (GIRKs), specifically known as GIRK1. It regulates heartbeat, forms heterotetrameric complexes with other GIRK subunits, and couples with neurotransmitter receptors in the brain to modulate neuronal excitability. Mutations or dysregulation are associated with atrial fibrillation and potentially other neurological conditions.
- Other names
- GIRK1G protein-activated inward rectifier potassium channel 1Kir3.1
02
Mechanism of action
Modulation of potassium ion conductance
03
Biological functions
Potassium ion import across plasma membranesRegulation of membrane potentialSignal transductionRegulation of cardiac rhythmModulation of synaptic transmissionRegulation of neuronal excitability
04
Disease associations
Familial atrial fibrillationCardiac arrhythmiaEpilepsy (potential)Addiction (potential)Down's syndrome (potential)Ataxia (potential)Parkinson’s disease (potential)
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