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Target intelligence / Profile preview
Potassium Inwardly Rectifying Channel Subfamily J Member 5 (KCNJ5)
- Target
- KCNJ5
- Molecular classification
- Integral membrane protein, Ion channel, Potassium channel
01
Overview
KCNJ5 encodes an inward-rectifier potassium channel subunit primarily expressed in the adrenal gland and pituitary. It plays a crucial role in maintaining resting membrane potential and regulating cellular excitability. Mutations in KCNJ5 can disrupt ion selectivity, leading to sodium influx, cellular depolarization, and dysregulation of calcium signaling. These alterations can result in diseases like aldosterone-producing adenomas, familial hyperaldosteronism type III, and Long QT syndrome type 13.
- Other names
- GIRK4Kir3.4CIRG protein-activated inward rectifier potassium channel 4KATP1LQT13
02
Mechanism of action
Modulation of potassium ion flow; influencing cell membrane potential.
03
Biological functions
Potassium transportRegulation of membrane potentialRegulation of cellular excitabilityG-protein regulation
04
Disease associations
HypertensionArrhythmiaAldosterone-producing adenomaFamilial hyperaldosteronism type IIILong QT syndrome type 13 (LQT13)
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