Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium inwardly rectifying channel subfamily J member 8 (None)
- Target
- None
- Molecular classification
- Inward Rectifier Potassium Channels, Ion channel
01
Overview
Kir6.1 is a pore-forming subunit of ATP-sensitive potassium (KATP) channels, which are crucial in linking cellular metabolism to membrane excitability. These channels are octameric complexes composed of four Kir6.x subunits (either Kir6.1 or Kir6.2) and four regulatory sulfonylurea receptor (SUR) subunits. Kir6.1 is predominantly expressed in vascular smooth muscle, where it forms functional KATP channels with SUR2B regulatory subunits, regulating vascular tone by controlling membrane potential in response to metabolic changes. Mutations affecting either KCNJ8 or its partner genes can lead to diseases such as Cantú syndrome.
- Other names
- Kir6.1KCNJ8
02
Mechanism of action
Inhibition by intracellular ATP; activation via Mg-nucleotide interaction with SUR
03
Biological functions
Regulation of vascular toneRegulation of membrane potentialMetabolic sensing
04
Disease associations
Cardiovascular diseaseCantú syndrome
05
Safety considerations
Gain-of-function mutations lead to hyperactivation of the channel, causing diseases.
Beyond the preview
Go deeper on Potassium inwardly rectifying channel subfamily J member 8 (None).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium inwardly rectifying channel subfamily J member 8 (None).