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Potassium transport ATPase alpha chain 1
- Molecular classification
- Enzyme, ATPase, Ion Transporter, P-type ATPase
01
Overview
Potassium transport ATPase alpha chain 1, also known as the gastric H+/K+ ATPase alpha subunit or proton pump, is a membrane-bound enzyme subunit encoded by the gene ATP4A in humans. It plays a central role in acid secretion in the stomach by exchanging intracellular hydrogen ions (H+) for extracellular potassium ions (K+) using energy derived from ATP hydrolysis. It is the primary target for proton pump inhibitors (PPIs).
- Other names
- Gastric H+/K+-ATPase α-subunitProton PumpPotassium-transporting ATPase alpha chain 1Gastric H(+)/K(+) ATPase subunit alpha
02
Mechanism of action
Irreversible inhibition of the H+/K+ ATPase, blocking gastric acid secretion
03
Biological functions
Ion transportGastric acid secretionATP hydrolysis
04
Disease associations
Gastroesophageal reflux disease (GERD)Peptic ulcerZollinger-Ellison syndromeHypochlorhydriaAchlorhydria
05
Safety considerations
Long-term PPI use associated with increased risk of fractures, infections, and nutrient deficiencies
06
Interacting drugs
Proton pump inhibitors (PPIs)
5 more in the full profile.
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