Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium voltage-gated channel-interacting protein 1 (KCNIP1)
- Target
- KCNIP1
- Molecular classification
- Ion channel regulatory subunit, Auxiliary subunit (Kv channel-interacting protein), EF-hand-containing protein, Neuronal calcium sensor family member
01
Overview
Potassium voltage-gated channel-interacting protein 1 (KCNIP1) is a cytosolic protein belonging to the neuronal calcium sensor (NCS) family of EF-hand calcium-binding proteins. It acts as a regulatory subunit for Kv4 (Shal-type) voltage-gated rapidly inactivating A-type potassium channels, modulating their channel density, inactivation kinetics, and recovery in a calcium-dependent, isoform-specific manner. KCNIP1 is crucial in controlling neuronal membrane excitability and may respond dynamically to changes in intracellular calcium. Alternative splicing produces multiple isoforms. Dysregulation or mutation of KCNIP1 has been associated with epilepsy and blood pressure abnormalities[1][2][3][7].
- Other names
- KChIP1KCIP1VABPvesicle APC-binding proteinA-type potassium channel modulatory protein 1Kv channel-interacting protein 1potassium channel-interacting protein 1
02
Mechanism of action
Modulates channel properties as a regulatory subunit (not a direct drug target; influences ion channel kinetics through protein-protein interaction)[1][2]
03
Biological functions
Regulation of voltage-gated A-type potassium channel activityModulation of neuronal membrane excitabilityCalcium ion bindingInfluence on inactivation kinetics and channel density
04
Disease associations
Epilepsy (idiopathic generalized epilepsy)Hypertension (diastolic hypertension)Other (neuroexcitability disorders)
05
Safety considerations
Potential for altered neuronal excitability if modulated non-specifically (theoretical, based on function; no established therapeutic targeting or clinical safety concerns reported)
Beyond the preview
Go deeper on Potassium voltage-gated channel-interacting protein 1 (KCNIP1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium voltage-gated channel-interacting protein 1 (KCNIP1).