Potassium voltage-gated channel modifier subfamily S member 1 (KCNS1)

KCNS1 encodes the **Potassium voltage-gated channel modifier subfamily S member 1**, a regulatory (electrically silent) subunit of the voltage-gated potassium channel family. It does not form functional channels by itself but modulates the activity of functional alpha subunits of other potassium channels, particularly KCNB1 and KCNB2, by altering their kinetics, voltage-dependence, and expression levels. KCNS1 is implicated in the regulation of neuronal excitability and modulation of action potential firing, and variants in KCNS1 have been associated with inherited episodes of pain. Dysfunction or altered expression of KCNS1-containing channel complexes may thus contribute to neuropathic pain conditions[2].

Other names

Delayed-rectifier potassium channel regulatory subunit KCNS1KCNS1hKv9.1Kv9.1Delayed-rectifier K(+) channel alpha subunit 1Delayed-rectifier potassium channel subunit Kv9.1Potassium voltage-gated channel subfamily S member 1potassium voltage-gated channel, delayed-rectifier, subfamily S, member 1voltage-gated potassium channel subunit Kv9.1

Modulation of KCNB1 and KCNB2 channel activity when forming heteromultimeric channels (influencing current kinetics, expression levels, voltage-dependence)