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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily A member 1 (Kv1.1)
- Target
- Kv1.1
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
Potassium voltage-gated channel subfamily A member 1 (Kv1.1) is a voltage-gated potassium channel that plays a crucial role in repolarizing neuronal membranes after action potentials, thereby controlling neuronal excitability and firing patterns. It forms tetrameric potassium-selective channels allowing potassium ions to pass through the cell membrane. Mutations or autoimmune reactions targeting Kv1.1 are associated with neurological disorders like Isaacs syndrome and episodic ataxia/myokymia syndromes.
- Other names
- HuK1RBK1MBKVoltage gated potassium channel HBK1Voltage gated potassium channel subunit Kv1.1Voltage-gated K+ channel HuKIAEMK
02
Mechanism of action
Not applicable without specific interacting drug information.
03
Biological functions
Regulation of neuronal excitabilityRepolarization of neuronal membranesControl of action potential duration and frequency
04
Disease associations
Episodic ataxiaMyokymiaIsaacs syndrome
05
Safety considerations
Potential for altered neuronal excitabilityAutoimmune reactions
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