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Potassium voltage-gated channel subfamily A member 10 (KCNA10)
- Target
- KCNA10
- Molecular classification
- Ion channel, Voltage-gated potassium channel, Shaker-related potassium channel
01
Overview
Potassium voltage-gated channel subfamily A member 10 (KCNA10) is a protein encoded by the KCNA10 gene and forms a voltage-gated potassium ion channel, specifically the Kv1.8 subunit. It plays key roles in excitable membranes by selectively mediating potassium ion flow in response to changes in membrane voltage. KCNA10 is involved in regulating a variety of physiological processes, including neuronal excitability, neurotransmitter release, heart rate, insulin secretion, and epithelial electrolyte transport. It is especially critical to the function of vestibular hair cells in the inner ear, where it shapes distinctive outwardly rectifying potassium conductances necessary for normal sensory processing of motion and balance. Its dysfunction has been linked to developmental and epileptic encephalopathies and episodic ataxia. KCNA10 belongs to the shaker-related subfamily of potassium channels and is uniquely regulated by cyclic GMP
- Other names
- KCNA10Kv1.8Kcn1Voltage-gated potassium channel subunit Kv1.8cyclic GMP gated potassium channelpotassium channel, voltage gated shaker related subfamily A member 10potassium channel shaker-related subfamily A member 10
02
Biological functions
Regulation of membrane potential and excitabilitySignal transductionNeurotransmitter releaseRegulation of heart rateInsulin secretionEpithelial electrolyte transportSmooth muscle contractionNeuronal excitabilityCell volume regulation
03
Disease associations
Epilepsy (Developmental and epileptic encephalopathy 32)Episodic ataxia (Type 1)Potential involvement in neurological and vestibular disorders
04
Safety considerations
Potential for impact on cardiac excitability and neural function if modulatedAltered vestibular function and neurological side effects if inhibited or genetically disturbed
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