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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily A member 5 (Kv1.5)
- Target
- Kv1.5
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
Kv1.5 is a voltage-gated potassium channel encoded by the KCNA5 gene. It plays a crucial role in repolarizing atrial action potentials and is therefore a potential therapeutic target for atrial fibrillation. It also contributes to other physiological processes, including insulin secretion and pulmonary vascular tone. Mutations or dysfunction of Kv1.5 are associated with atrial fibrillation, sudden cardiac death, and pulmonary hypertension.
- Other names
- KCNA5K(V)1.5Potassium channel, voltage-gated shaker-related subfamily A, member 5
02
Mechanism of action
Channel blocker (Note: this requires more specific drug information to detail accurately)
03
Biological functions
Regulation of membrane potentialCardiac action potential repolarizationRegulation of insulin secretionRegulation of pulmonary vascular toneTransmembrane potassium transport
04
Disease associations
Atrial fibrillationSudden cardiac deathPulmonary hypertension
05
Safety considerations
Potential for pro-arrhythmic effects if blocking Kv1.5 in ventricular myocytes.
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