Potassium voltage-gated channel subfamily A regulatory beta subunit 1 (KCNAB1)

Potassium voltage-gated channel subfamily A regulatory beta subunit 1 (KCNAB1) encodes a cytoplasmic regulatory (beta-1) subunit of the shaker-like voltage-gated potassium channels. The KCNAB1 protein forms complexes with Kv1 alpha subunits and modulates the gating kinetics and inactivation, particularly contributing to fast N-type inactivation. This finely tunes potassium currents that control neuronal repolarization and repetitive firing, as well as transient and slow K+ currents in cardiac myocytes. KCNAB1 also possesses NADPH-dependent aldo-keto reductase activity, which can influence channel function. Mutations and changes in KCNAB1 activity are implicated in disorders such as epilepsy, episodic ataxia, and contribute to cardiovascular rhythm control and vascular smooth muscle biology[1][2][3].

Other names

KCNA1BhKvBeta3AKR6A3Kvb1.3hKvb3KV-BETA-1HKvBeta3HKvb3potassium channel beta 3 chainpotassium channel beta3 subunitpotassium channel shaker chain beta 1apotassium channel, voltage-gated subfamily A regulatory beta subunit 1potassium voltage-gated channel subfamily A member regulatory beta subunit 1potassium voltage-gated channel, shaker-related subfamily, beta member 1

Modulation of N-type (fast) inactivation of Kv channels, affecting neuronal and cardiac excitability. Drugs that modulate Kv channel availability, repolarization, or inactivation may act via complexes containing KCNAB1.