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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily C member 1 (Kv3.1)
- Target
- Kv3.1
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel, Delayed rectifier potassium channel
01
Overview
Potassium voltage-gated channel subfamily C member 1 (KCNC1), also known as Kv3.1, is an integral membrane protein that functions as a voltage-gated potassium channel. It mediates the voltage-dependent permeability of potassium ions across excitable membranes, playing a crucial role in repolarizing the membrane potential after action potentials. Kv3.1 channels are predominantly expressed in neurons that fire at high frequency, and are essential for enabling high-frequency action potential generation. Variants or dysfunctions in KCNC1 have been associated with neurological disorders due to its critical role in neuronal excitability.
- Other names
- KCNC1
02
Biological functions
Regulation of membrane potentialAction potential repolarizationPotassium ion transmembrane transportRegulation of neuronal excitability
03
Disease associations
Neurological disorders
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