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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily C member 2 (KCNC2)
- Target
- KCNC2
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
Potassium voltage-gated channel subfamily C member 2 (KCNC2) is a protein-coding gene that encodes a voltage-gated potassium channel, primarily expressed in the brain. It belongs to the delayed rectifier class of potassium channels and plays a critical role in mediating the voltage-dependent permeability of excitable membranes to potassium ions. The main physiological function of KCNC2 is to enable rapid repolarization during action potentials, supporting high-frequency neuronal firing without significant accommodation or fatigue. Mutations or dysfunctions in KCNC2 have been linked to neurological disorders such as Developmental And Epileptic Encephalopathy 103 and other developmental epileptic encephalopathies.
- Other names
- Voltage-gated potassium channel KCNC2Shaw-like potassium channelKv3.2Shaw-like K+ channelVoltage-gated K+ channel KCNC2
02
Mechanism of action
Modulates neuronal excitability by regulating potassium ion flow across cell membranes.
03
Biological functions
Regulation of membrane potentialNeuronal excitabilityRhythmic electrical activityDelayed rectifier potassium current generationLong-range synchronization of gamma oscillationsModulation of circadian rhythm firing
04
Disease associations
Developmental And Epileptic Encephalopathy 103EpilepsyNeurological disorders
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