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Potassium voltage-gated channel subfamily C member 3 (Kv3.3)
- Target
- Kv3.3
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
Potassium voltage-gated channel subfamily C member 3 (KCNC3 or Kv3.3) is a protein that forms a voltage-gated potassium channel. This channel is crucial for the rapid repolarization of action potentials in fast-spiking neurons, especially in brain regions like the cerebellum. KCNC3 plays a significant role in regulating neuronal excitability, neurotransmitter release, and synaptic transmission. Mutations in KCNC3 are linked to spinocerebellar ataxia type 13 (SCA13), a neurodegenerative disorder affecting movement coordination. The channel is a tetramer, with each subunit containing six transmembrane domains.
- Other names
- Voltage-gated potassium channel KCNC3KSHIIID
02
Mechanism of action
Modulation of K+ flux through voltage-gated channels
03
Biological functions
Regulation of neuronal excitabilityRapid repolarization of fast-firing neuronsRegulation of neurotransmitter releaseRegulation of synaptic transmission
04
Disease associations
Neurodegenerative diseaseSpinocerebellar ataxia type 13 (SCA13)
05
Safety considerations
Potential for altered neuronal signaling if channel function is disruptedSide effects related to altered neuronal excitability
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