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Potassium voltage-gated channel subfamily D member 3 (Kv4.3)
- Target
- Kv4.3
- Molecular classification
- Voltage-gated potassium channel, Ion channel, Shal-related subfamily
01
Overview
Kv4.3 (Potassium voltage-gated channel subfamily D member 3) is a voltage-gated potassium channel encoded by the KCND3 gene. It is a key component of the transient outward potassium current (Ito), which plays a crucial role in the early repolarization phase of cardiac action potentials and contributes to A-type currents in neurons. Its function is modulated by auxiliary proteins like KChIPs and NCSs and post-translational modifications. Mutations or dysregulation of Kv4.3/KCND3 have been linked with cardiac arrhythmias including Brugada syndrome and neurological disorders.
- Other names
- KCND3
02
Mechanism of action
Block Kv4.3 channels
03
Biological functions
Regulation of neuronal firingCardiac repolarizationSetting plateau voltages in cardiac action potentialsRegulation of excitability
04
Disease associations
Cardiac arrhythmiasBrugada syndromeNeurological disorders
05
Safety considerations
ArrhythmiasPotential for altered neuronal excitability
06
Interacting drugs
Flecainide
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