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Potassium voltage-gated channel subfamily D member 3 with KChIP2 coexpression complex (Kv4.3/KChIP2/Ito)
- Target
- Kv4.3/KChIP2/Ito
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Tetrameric protein complex
01
Overview
The Kv4.3/KChIP2/Ito complex is a voltage-gated potassium channel complex primarily responsible for the cardiac transient outward potassium current (Ito). It is composed of the Kv4.3 alpha subunit (encoded by the KCND3 gene) and the auxiliary subunit KChIP2. This complex plays a crucial role in regulating the early repolarization phase of the cardiac action potential, influencing heart rate and susceptibility to arrhythmias. Dysfunction or mutations in this complex are associated with cardiac disorders like Brugada syndrome and early repolarization pattern.
- Other names
- KCND3Kv4.3KChIP2Ito
02
Mechanism of action
Channel blocker
03
Biological functions
Regulation of cardiac action potential durationEarly repolarization of cardiomyocytesRegulation of neuronal excitabilityPotassium ion transmembrane transport
04
Disease associations
Brugada SyndromeArrhythmiaEarly Repolarization PatternNeurological disorders (potential)
05
Safety considerations
Pro-arrhythmic potentialPotential for drug-induced Brugada syndrome
06
Interacting drugs
Flecainide
1 more in the full profile.
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