Potassium voltage-gated channel subfamily H member 6 (KCNH6)

Potassium voltage-gated channel subfamily H member 6 (KCNH6) is a pore-forming alpha subunit of a voltage-gated inwardly rectifying potassium channel, belonging to the Eag (ether-à-go-go) related gene family. This large transmembrane protein forms tetrameric potassium-selective channels responsible for regulating ion movement across the membrane in response to changes in membrane voltage, with important roles in cellular excitability, action potential repolarization, and tissue-specific physiological functions such as neurotransmitter release, heart rate regulation, and insulin secretion. It is structurally and functionally related to other family members such as KCNH2 (hERG), which is a well-known antiarrhythmic drug target. Although KCNH6’s detailed disease roles and drug interactions are less well characterized than KCNH2, aberrations are associated with several pathologies, and safety concerns may be inferred due to the functional family’s importance in cardiac and neuronal electrophysiology[1][3][6].

Other names

ERG-2Eag-related protein 2Ether-a-go-go-related gene potassium channel 2HERG2Kv11.2hERG-2erg2voltage-gated inwardly rectifying potassium channel KCNH6voltage-gated potassium channel subunit Kv11.2potassium voltage-gated channel, subfamily H (eag-related), member 6potassium voltage-gated channel subfamily H member 6[1][3][5]

Blockade/modulation of potassium flux through voltage-gated ion channel; alteration of membrane repolarization kinetics[2][3][6]