Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium voltage-gated channel subfamily J member 11 (KCNJ11)
- Target
- KCNJ11
- Molecular classification
- Ion channel, Potassium channel, Inward rectifier potassium channel
01
Overview
Potassium voltage-gated channel subfamily J member 11 (KCNJ11) encodes the Kir6.2 protein, a key component of ATP-sensitive potassium (KATP) channels. These channels are integral membrane proteins that allow potassium ions to flow more readily into the cell than out. The activity of these channels is regulated by G-proteins and they function in association with sulfonylurea receptors (SUR), forming hetero-octameric complexes critical for cellular excitability and insulin secretion. Mutations or polymorphisms in KCNJ11 are linked with congenital hyperinsulinism, permanent neonatal diabetes mellitus and type II diabetes mellitus.
- Other names
- Kir6.2ATP-sensitive inward rectifier potassium channel 11
02
Mechanism of action
Sulfonylureas bind to the SUR subunit of the KATP channel, inhibiting its activity and promoting insulin secretion.
03
Biological functions
Regulation of insulin secretionCardiac conductionMaintenance of resting membrane potentialRegulation of cellular excitability
04
Disease associations
Congenital hyperinsulinismPermanent neonatal diabetes mellitusType II diabetes mellitus
05
Safety considerations
Hypoglycemia (with sulfonylurea drugs)Cardiac arrhythmias
06
Interacting drugs
Sulfonylureas
Beyond the preview
Go deeper on Potassium voltage-gated channel subfamily J member 11 (KCNJ11).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium voltage-gated channel subfamily J member 11 (KCNJ11).