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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily J member 2 (Kir2.1)
- Target
- Kir2.1
- Molecular classification
- Ion channel, Potassium channel, Inward rectifier potassium channel, Voltage-gated ion channel
01
Overview
KCNJ2 encodes Kir2.1, an inward rectifier potassium channel primarily expressed in heart and skeletal muscle. Kir2.1 plays a critical role in maintaining resting membrane potential and repolarizing cardiac muscle cells after each heartbeat. Mutations in KCNJ2 are associated with Andersen-Tawil syndrome and short QT syndrome, both characterized by cardiac arrhythmias and other symptoms. The channel's activity is regulated by PIP2 binding, and its inward rectification property arises from magnesium ion blockage of outward current.
- Other names
- KCNJ2Inward rectifier potassium channel subfamily J member 2
02
Mechanism of action
N/A
03
Biological functions
Regulation of membrane potentialCardiac repolarizationRegulation of muscle contractionPotassium ion transport
04
Disease associations
Andersen-Tawil syndromeShort QT syndromeCardiac arrhythmiaPeriodic paralysis
05
Safety considerations
Potential for cardiac arrhythmias due to altered potassium channel function
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