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Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1)
- Target
- KCNQ1
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
Potassium voltage-gated channel subfamily KQT member 1 (KCNQ1), also known as Kv7.1 or KvLQT1, is a voltage-gated potassium channel protein crucial for the electrical activity of the heart and inner ear. It mediates the slow delayed rectifier potassium current (I_Ks) in cardiac cells, essential for repolarization during the cardiac action potential. Mutations in KCNQ1 are associated with Long QT syndrome and other cardiac and auditory disorders. Its function can be modulated by KCNE beta-subunits, creating challenges for selective pharmacological targeting. Kv7.1 forms tetrameric channels and does not coassemble with other KCNQ family members like Kv7.2 or Kv7.3.
- Other names
- Kv7.1KvLQT1
02
Mechanism of action
Modulation of potassium ion flow across cell membranes
03
Biological functions
Cardiac repolarizationPotassium ion transportRegulation of neuronal excitabilityEndolymph secretion
04
Disease associations
Long QT syndromeFamilial atrial fibrillationJervell-Lange-Nielsen syndrome
05
Safety considerations
Potential for cardiac arrhythmiasTissue-specific effects of modulatorsDrug interactions with other QT-prolonging agents
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