Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4)
- Target
- KCNQ4
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel, KCNQ channel
01
Overview
Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4) is a voltage-gated potassium channel crucial for regulating membrane potential and electrical excitability, particularly in auditory sensory cells and neurons. It mediates outward potassium currents, contributing to action potential repolarization and regulating neuronal firing frequency. Mutations in KCNQ4 are associated with sensorineural hearing loss. The channel's activity is modulated by auxiliary proteins and post-translational modifications.
- Other names
- Kv7.4KQT-like 4Potassium channel, voltage gated KQT-like subfamily Q, member 4
02
Mechanism of action
Potassium channel modulation (channel opener or blocker)
03
Biological functions
Regulation of membrane potentialRegulation of neuronal excitabilityPotassium ion transmembrane transportAction potential repolarization
04
Disease associations
Sensorineural hearing lossEpilepsy (potential)Neurological disorders (potential)
05
Safety considerations
Potential for affecting cardiac action potential durationOff-target effects on other potassium channels
Beyond the preview
Go deeper on Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium voltage-gated channel subfamily KQT member 4 (KCNQ4).