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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily KQT member 5 (Kv7.5)
- Target
- Kv7.5
- Molecular classification
- Voltage-gated potassium channel, KCNQ/Kv family, Ion channel
01
Overview
Kv7.5 is a voltage-gated potassium channel subunit that belongs to the KCNQ/Kv7 family. It forms tetrameric channels, either as homomers or heteromers with other Kv7 subunits, and contributes to the M-current, regulating membrane excitability in neurons and smooth muscle cells. Dysfunction is implicated in epilepsy, hypertension, and other disorders.
- Other names
- KCNQ5
02
Mechanism of action
Modulation of M-currents by drugs (details not provided in text)
03
Biological functions
Regulation of membrane potentialRegulation of excitabilityPotassium ion conductance
04
Disease associations
EpilepsyHypertensionCardiovascular diseasesHearing Loss
05
Safety considerations
Potential for neuronal hyperexcitabilityPotential for altered vascular tone
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