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Potassium Voltage-Gated Channel Subfamily Q Member (Kv7)
- Target
- Kv7
- Molecular classification
- Ion channel, Voltage-gated potassium channel
01
Overview
Kv7 channels, also known as KCNQ channels, are a family of voltage-gated potassium (K+) channels encoded by the KCNQ1–KCNQ5 genes. These channels play critical roles in regulating cellular excitability in various tissues including the heart, brain, muscles (smooth and skeletal), sensory cells (auditory and vestibular organs), and epithelia. They are tetrameric assemblies of six-transmembrane-segment α-subunits, with S1–S4 forming the voltage-sensing domain (VSD) and S5–S6 forming the pore domain. Activation is voltage-dependent and requires PIP2. Dysfunction leads directly to major neurological and cardiovascular disorders.
- Other names
- KCNQ channelsKv7.1Kv7.2Kv7.3Kv7.4Kv7.5
02
Mechanism of action
Enhances Kv7 channel activity, stabilizing resting membrane potential
03
Biological functions
Regulation of cellular excitabilityRegulation of resting membrane potentialRegulation of action potential thresholdCardiac repolarizationAuditory functionEpithelial transportMuscle contraction regulationNeural plasticityBehavior modulation
04
Disease associations
EpilepsyCardiac arrhythmiasDeafnessLong QT syndrome
05
Safety considerations
Potential for cardiac or neurological side effects due to altered excitabilityVaried effects depending on subunit composition and tissue distribution
06
Interacting drugs
Ezogabine
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