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Potassium Voltage-Gated Channel Subfamily Q Member 1 (KvLQT1)
- Target
- KvLQT1
- Molecular classification
- Ion channel, Voltage-gated potassium channel, Potassium channel
01
Overview
KvLQT1 (also known as Kv7.1) is a voltage-gated potassium channel subunit encoded by the KCNQ1 gene. It is a key component of the IKs channel complex in cardiac tissue, responsible for the slow delayed rectifier potassium current. Mutations in KCNQ1 can lead to Long QT syndrome type 1 (LQT1) and deafness. The channel is modulated by KCNE subunits and phosphorylation, affecting cardiac repolarization and epithelial ion transport.
- Other names
- Kv7.1KCNQ1IKs channel subunit
02
Mechanism of action
Blockade of KvLQT1 currents, Modulation of cAMP responses
03
Biological functions
Cardiac repolarizationEpithelial ion transportRegulation of water/salt homeostasisRegulation of action potential duration
04
Disease associations
Long QT syndrome type 1 (LQT1)DeafnessArrhythmiaAtrial fibrillation
05
Safety considerations
ArrhythmiasSudden death
06
Interacting drugs
293B
1 more in the full profile.
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