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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily Q member 3 (KCNQ3)
- Target
- KCNQ3
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated potassium channel
01
Overview
Potassium voltage-gated channel subfamily Q member 3 (KCNQ3) is a pore-forming subunit of voltage-gated potassium channels, specifically M-channels. It plays a crucial role in regulating neuronal excitability by transporting potassium ions out of cells and transmitting the M-current, which acts as a brake on neuronal activity. Mutations in KCNQ3 are associated with neurological disorders such as benign familial neonatal seizures.
- Other names
- Kv7.3EBN2BFNC2
02
Mechanism of action
Voltage-gated potassium channel modulation
03
Biological functions
Regulation of neuronal excitabilityPotassium ion transportGeneration and propagation of action potentialsM-current transmission
04
Disease associations
Seizures, Benign Familial Neonatal, 2 (BFNC2)Benign Neonatal Seizures
05
Safety considerations
Potential for off-target effects due to potassium channel involvement in various tissuesRisk of cardiac arrhythmias or other neurological side effects
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