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Potassium Voltage-Gated Channel Subfamily Q Member 4 (KCNQ4)
- Target
- KCNQ4
- Molecular classification
- Ion channel, Potassium voltage-gated channel, Kv7/KQT family
01
Overview
KCNQ4 is a voltage-gated potassium channel essential for maintaining proper potassium ion concentrations within inner ear structures and enabling efficient conversion of sound waves into electrical nerve signals for hearing. It is expressed in sensory cells of the inner ear and along auditory pathways. Mutations in KCNQ4 are associated with nonsyndromic sensorineural deafness (DFNA2). It is a target for drugs aimed at treating epilepsy, neuropathic pain, or potentially certain forms of deafness.
- Other names
- Kv7.4DFNA2DFNA2APotassium voltage-gated channel subfamily KQT member 4
02
Mechanism of action
Channel activation or inhibition to modulate potassium ion flow and neuronal excitability.
03
Biological functions
Ion channel activityVoltage-gatingRegulation of membrane potentialRegulation of neuronal excitability
04
Disease associations
Nonsyndromic Sensorineural Deafness Type 2 (DFNA2)Age-related Hearing Loss
05
Interacting drugs
Retigabine / Ezogabine
1 more in the full profile.
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