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Target intelligence / Profile preview
Potassium voltage-gated channel subfamily Q member 7 (Kv7)
- Target
- Kv7
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, KCNQ channel
01
Overview
Potassium voltage-gated channel subfamily Q member 7 (Kv7 or KCNQ) channels are a family of voltage-gated potassium channels crucial for controlling membrane excitability in neurons, cardiac muscle, and other tissues. These channels mediate inhibitory potassium currents, stabilizing resting membrane potential and repolarizing cells after action potentials. Dysfunction or genetic mutations can lead to diseases characterized by increased cellular excitability, such as epilepsy, cardiac arrhythmias (Long QT syndrome), and deafness. Small-molecule activators are being developed as therapeutic agents to enhance channel opening and restore normal function.
- Other names
- KCNQ channelKCNQKv7.1Kv7.2Kv7.3Kv7.4Kv7.5
02
Mechanism of action
KCNQ channel activators enhance channel opening, increasing potassium ion efflux and reducing membrane excitability.
03
Biological functions
Regulation of membrane potentialRegulation of neuronal excitabilityCardiac repolarizationMuscle contractionRegulation of cellular excitability
04
Disease associations
EpilepsyLong QT syndromeCardiac arrhythmiaDeafnessNeuronal hyperexcitability
05
Safety considerations
QT prolongationCNS side effects
06
Interacting drugs
Retigabine/Ezogabine
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