Potassium voltage-gated channel subfamily V member 2 (KCNV2 (Kv8.2))

Potassium voltage-gated channel subfamily V member 2 is a protein encoded by the KCNV2 gene in humans. It acts as a modulatory or "silent" subunit within the family of voltage-gated potassium channels, meaning it does not form functional channels on its own but modifies the properties of other potassium channel alpha-subunits when co-expressed. This modulation includes shifting the threshold and half-maximal activation to more negative values, thereby influencing neuronal excitability and signal transduction in tissues where it is expressed, such as the retina and brain. Mutations in KCNV2 are associated with specific forms of inherited retinal disease, most notably cone dystrophy with supernormal rod response (CDSRR). There are currently no well-established drugs that directly target this specific subunit; its primary clinical relevance lies in genetic diagnosis for certain retinal diseases rather than as a direct pharmacological target.

Other names

KCNV2Kv8.2KV11.1RCD3BPotassium voltage-gated channel modifier subfamily V member 2