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POTE ankyrin domain family member J (POTEJ)
- Target
- POTEJ
- Molecular classification
- Other (Ankyrin repeat domain containing protein), POTE family protein
01
Overview
POTE ankyrin domain family member J (POTEJ) is a protein coding gene in humans and a member of the ankyrin repeat domain-containing POTE protein family[3][4]. It is predicted to bind protein kinases and play a role as a structural constituent of the postsynaptic actin cytoskeleton, axonogenesis, and cell motility, with gene expression noted across diverse tissues[3][4]. Mutational data from cancer cell lines and an association with focal segmental glomerulosclerosis suggest possible disease relevance, though POTEJ is not currently established as a clinical or therapeutic target[3][4][6]. Genetic identifiers include HGNC: 37094, NCBI Gene: 653781, Ensembl: ENSG00000222038, and UniProt: P0CG39[3][4][8].
- Other names
- POTEJPOTE ankyrin domain family, member JPOTE2beta
02
Mechanism of action
null
03
Biological functions
Protein kinase bindingStructural constituent of postsynaptic actin cytoskeletonAxonogenesisCell motility
04
Disease associations
Cancer (mutations noted in the COSMIC cancer database; association but not a validated cancer driver)Focal segmental glomerulosclerosis 2 (association reported in GeneCards)
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