POU class 5 homeobox 1 pseudogene 3 (POU5F1P3)

POU class 5 homeobox 1 pseudogene 3 (POU5F1P3) is classified as a pseudogene, meaning it is a genomic DNA sequence similar to a functional gene (here, POU5F1/OCT4, a key pluripotency transcription factor), but is generally thought to lack the ability to encode a functional protein[1][3]. POU5F1P3 shares high sequence similarity with POU5F1 and is transcriptionally active in some cancers, where its expression—like its parental gene—may be altered and associated with tumor biology. Its function is not well-established; it is predicted to regulate DNA-templated transcription, potentially by acting on RNA or modulating the expression or stability of the parental gene transcript. POU5F1P3 and related pseudogenes are increasingly being studied for their roles as biomarkers or modulators in oncology due to their expression in cancer, but this molecular entity itself is not a validated therapeutic target and does not code for a functional receptor, enzyme, or protein[1][3].\n\nKey notes:\n- POU5F1P3 is a pseudogene and does not encode a functional protein, distinguishing it from its parent gene POU5F1/OCT4, which is a transcription factor critical for stem cell pluripotency and cancer biology[2][3].\n- While POU5F1P3 may have regulatory roles (potentially through RNA-mediated mechanisms) and is differentially expressed in cancers, it is neither a receptor nor a direct therapeutic target at present[1][3].\n- No known drugs directly target POU5F1P3 or its product, if any (other than possibly serving as a biomarker in research settings)[1][3].

Other names

POU5F1P3POU5FLC12OCT4-pg3Octamer-binding protein 3Octamer-binding transcription factor 3OTF3LPOU5F1LPOU domain class 5 transcription factor 1 pseudogene 3POU domain transcription factor OCT4-pg3