Target intelligence / Profile preview

POU class 5 homeobox 1 pseudogene 4 (POU5F1P4)

Target
POU5F1P4
Molecular classification
Pseudogene, Homeobox gene family, Transcription factor (pseudogene), POU domain family
01

Overview

POU class 5 homeobox 1 pseudogene 4 (POU5F1P4) is a human processed pseudogene located on chromosome 1[1][2][7]. It is a non-coding DNA sequence related to the protein-coding gene POU5F1, a key pluripotency transcription factor, but POU5F1P4 itself does not produce a functional protein product[1][2]. The gene has been annotated as participating in DNA binding and transcription factor activity by sequence similarity, but as a pseudogene, it is not believed to encode an active protein or serve as a therapeutic target[2][1]. There are no established drugs, clinical biomarkers, or known safety concerns related to POU5F1P4, and it is not considered an actionable therapeutic target.

Other names
POU5FLC1Oct4-pg4POU domain class 5, transcription factor 1 pseudogene 4POU domain transcription factor OCT4-pg4POU domain, class 5, transcription factor 1 pseudogene 4Octamer-binding transcription factor 3Octamer-binding protein 3OCT3OCT4OTF-3OTF3Oct-3Oct-4
02

Mechanism of action

Not applicable (pseudogene, no druggable protein)

03

Biological functions

Not protein-coding; thus, no direct biological function as a proteinAnnotation databases predict DNA binding and transcription factor activity, but do not confirm activity due to its nature as a pseudogene[2][1]
04

Disease associations

Possible association with colorectal cancer as an annotated link, but not established as a functional disease driver[2]No confirmed disease-modifying role

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